Understanding the 5-Panel DOT Return-to-Duty Drug Test

April 14, 2025

Ophthalmologist's Department

The 5-panel drug test is a cornerstone of the Department of Transportation (DOT) drug testing program, particularly for return-to-duty scenarios. It’s designed to ensure that employees in safety-sensitive positions are free from substances that could impair their ability to perform their duties safely.

What is the 5-Panel DOT Drug Test?

The 5-panel DOT drug test screens for five categories of drugs, but within these categories, it actually detects 15 different substances. This test is widely regarded as the gold standard, not just for DOT-mandated testing but also for many employers who adopt it for their own workplace testing programs.

Here’s what the 5-panel test screens for:

  1. Marijuana (THC)
  2. Cocaine
  3. Amphetamines (including Amphetamine, Methamphetamine, MDMA, MDA, and MDEA)
  4. Opioids (including Codeine, Morphine, 6-AM [Heroin], Oxymorphone, Oxycodone, Hydromorphone, and Hydrocodone)
  5. Phencyclidine (PCP)

Why is it Important for Return-to-Duty Testing?

Return-to-duty testing is required for employees who have violated DOT drug and alcohol regulations. It’s a critical step in ensuring that these individuals are ready to safely resume their safety-sensitive duties. The 5-panel test is used to confirm that the employee is no longer using prohibited substances.

Why Do Employers Use the 5-Panel Test?

Many employers adopt the 5-panel test as their standard for workplace drug testing, even outside of DOT requirements. Its comprehensive scope and reliability make it an effective tool for maintaining a drug-free workplace.

Final Thoughts

The 5-panel DOT drug test plays a vital role in promoting safety and compliance in safety-sensitive industries. Whether it’s used for return-to-duty testing or as a general workplace standard, this test helps ensure that employees are fit for duty and that workplaces remain safe for everyone.

Feel free to share this post to spread awareness about the importance of the 5-panel DOT drug test!

Karishma Sarfani

Karishma is a Qualified Substance Abuse Professional (SAP) with a background in mental health and substance abuse counseling, holding credentials as an MS, LCDC, ICADC, CADC II, CSAC, CASAC II, LPC, and EMDR-trained therapist. Inspired by personal experiences with addiction and mental health challenges in her community, she has dedicated her career to supporting individuals on their journey to recovery and success.